Inhaler Waste Firing
Delivered Dose Uniformity (DDU) testing is a critical requirement for Metered Dose Inhalers (MDIs), Dry Powder Inhalers (DPIs), Aqueous Droplet Inhalers (ADIs), Nebulisers and other aerosolised products. Testing orally inhaled and nasal drug products (OINDPs) is labour intensive. When done manually, because of the steps involved, results can vary analyst to analyst. Automating testing not only eliminates variations in device handling, firing force, shake technique and actuation, but increases throughput. Automation also minimizes risk to the operator, by eliminating exposure to the tested product during waste and collection firing as well as preventing strain injuries cause by repetitive manual shaking.
The Xelair® waste shot firing unit is equipped with a vacuum channel, providing precise flow control (to a method set point) and instrumentation for flow monitoring. Once the inhaler is automatically actuated it will be advanced into position sealing with the waste collection mouthpiece before the vacuum channel valve is switched to initiate the firing of the waste dose. A balance can be included to weigh devices before and after firing. All inhaler types and styles can be accommodated including batch storage. For Dry Powder Inhalers, the waste dose is automatically collected by a ‘reverse jet pulse filter’ unit. The unique design of the filter ensures there is no degradation of flow and no operator exposure through the use of safe change valve technology. The inhaler waste shot firing unit can be installed as a standalone unit or integrated into Astech’s Xelair® or Xelox® fully automated systems. With these systems, multiple inhalers can be processed in parallel, thereby increasing throughput.
Astech’s inhaler waste shot firing system allows you to automatically control the same variables such as flow, force, speed and distance for waste firing as with test dose collection to ensure consistent dosing across the life of the multi dose device. Recorded data includes; dosing airflow rate, pressure drop, flow duration and dose firing detection.
Relovex® allows simple method set up and selection. For MDIs the Xelair® Waste Shot Firer uses Astech’s patented linear shaking technology. Astech understands the unique shaking requirements of different devices and can offer several options. For more about shaking options read about our Xelair® Shaker.
Xelair® Range for Inhaler Device Testing including:
Delivered Dose Uniformity (DDU)
Waste Firing
Linear or Rotary Shaking
Flow Generation & Measurement
Actuation Through Life & Dose Counter Verification
Emitted Dose/Weight
Our ground breaking series of products for testing Delivered Dose Uniformity as well as standalone workstations for waste firing, shaking & firing, dose collection and physical device testing including actuation through life. Build your automated inhaler testing facility by selecting from our range of systems:
Xelair® series products for Automated Delivered Dose Uniformity
Xelize® series products for Automated Andersen Cascade (ACI) testing
Xelox® series products for Automated NGI testing
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